WASHINGTON — Senator Joe Manchin III, Democrat of West Virginia, mentioned on Sunday that he couldn’t assist President Biden’s signature $2.2 trillion social security internet, local weather and tax invoice, all however dooming his occasion’s drive to go the measure as written.

“I can not vote to proceed with this piece of laws,” Mr. Manchin mentioned on “Fox Information Sunday,” citing issues about including to the nationwide debt. “I’ve tried all the pieces humanly doable. I can’t get there. It is a no.”

The feedback from Mr. Manchin, an important Democratic holdout, dealt the newest, maybe deadly blow to the centerpiece of Mr. Biden’s home agenda. With Republicans united in opposing the laws, Democrats wanted to safe the vote of each senator of their occasion for the measure to go an evenly divided Senate.

For months, Mr. Manchin had huddled privately with Mr. Biden and his high officers in an try to safe a compromise. His objections compelled the White Home to considerably curtail the scope of the package deal and take away sure items, together with the creation of a clear electrical energy program and a plan to ban new oil drilling off the Atlantic and Pacific coasts.

As early as final week, at the same time as Mr. Biden confirmed that efforts to go the laws had stalled, he waxed optimistic, saying that talks with Mr. Manchin would proceed and that he believed that “we’ll bridge our variations and advance the Construct Again Higher plan.”

The Senate left for the vacations this week with out finishing work on the sprawling package deal, vowing to proceed as soon as senators reconvene in early January. However Mr. Manchin on Sunday appeared to shut the door on additional substantive talks, complaining that his colleagues had been spending months using tips to make the laws seem more cost effective fairly than really paring it down.

“They’re simply attempting to make the adjustment for the time to suit the cash or the cash to suit the time,” Mr. Manchin mentioned. “Not altering our strategy, not concentrating on issues we must be doing.”

His feedback are certain to infuriate his Democratic colleagues, who had hoped to go the laws this 12 months. It stays to be seen whether or not they may reply by considerably modifying the invoice within the hopes of salvaging one thing that may go.

“I feel he’s going to have numerous explaining to do to the individuals of West Virginia,” mentioned Senator Bernie Sanders, the Vermont impartial who heads the Senate Price range Committee, calling for a vote on the Senate ground on the laws regardless of Mr. Manchin’s feedback.

“We’ve been coping with Mr. Manchin for month after month after month,” he added, talking on CNN’s “State of the Union.” “But when he doesn’t have the braveness to do the fitting factor for the working households of West Virginia and America, let him vote no in entrance of the entire world.”

Chris Cameron contributed reporting.